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Eligibility should be determined through an authorised clinical trial rather than through self-directed use

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Vitamin B12 is especially important, as GLP-1 receptor agonists may reduce B12 absorption over time, and combining semaglutide with B12 supplementation is increasingly recommended by providers

doi:10.1179/1476830513y.0000000066 81

This titration helps reduce side effects and ensures the best possible results for each patient

The STEP trials demonstrated that semaglutide 2.4 mg weekly produced 14.9% weight loss versus 2.4% with placebo over 68 weeks in adults with obesity